Herzlich Willkommen im Arbeitskreis von Prof. Tanja Weil

Synthese von Makromolekülen

Der Arbeitskreis für die Synthese von Makromolekülen entwickelt innovative Synthesekonzepte zur Herstellung funktionaler Makromoleküle und Hybridmaterialien durch komplexe molekulare Designstrategien, um zukünftige Herausforderungen in der Biomedizin und Materialwissenschaft zu lösen.

Journal Cover

Medien und Veranstaltung

SupraChem 2022

Wir sind stolz darauf, diese alle zwei Jahre stattfindende Reihe, die alle supramolekularen Chemiker und Wissenschaftler aus verwandten Bereichen versammelt, mitzuorganisieren. mehr

Fighting cancer, Trojan Horse-style

LinkedIn News (Bild aus Originalartikel übernommen) mehr

Wie Nerven nachwachsen können

Artikel im Newsroom der Max-Planck-Gesellschaft
(Bild: Wie geschädigte Nerven nachwachsen können. © mattweis basierend auf Vorlagen des MPI für Polymerforschung)

Highlight Publikationen

Ion and Molecular Sieving With Ultrathin Polydopamine Nanomembranes

We report the first free-standing, ultrathin (10-17 nm) nanomembranes composed entirely of polydopamine (PDA) via an easily scalable electropolymerization strategy, which feature well-defined nanochannels, as well as abundant amine and catechol groups, for efficient ion and molecular sieving. mehr

Macrocyclic Dual-Locked “Turn-On” Drug for Selective and Traceless Release in Cancer Cells

We report drug cyclization based on dynamic covalent linkages to devise a dual lock for the small-molecule anticancer drug, that can only be activated in the unique intracellular chemical environment in cancer cells
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Data-mining unveils structure–property–activity correlation of viral infectivity enhancing self-assembling peptides

Through a data-mining approach, structure-property-activity correlations were found in self-assembling peptide sequences for enhancing viral transduction efficiency, enabling a pathway towards efficient gene therapy.
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Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments

We designed dual responsive dynamic covalent peptide tags combining a pH responsive boronate ester with fast association and dissociation rates, and a redox-active disulfide with slow formation and dissociation rate. In this way, some limitations in linker design can be overcome for controlled release in the tumor microenvironment. mehr

Controlled Supramolecular Assembly inside Living Cells by Sequential Multi-staged Chemical Reactions.

A modular platform that incorporates intricate molecular recognition, immolative, and rearrangement chemistry to achieve synthetic assembly within living cells. mehr

Photo-controlled Dopamine Polymerization on DNA Origami with low Nanometer Resolution.

Temporal and spatial control over polydopamine formation on the nanoscale can be achieved by installing an irradiation-sensitive polymerization system on DNA origami. mehr

Detection of Few Hydrogen Peroxide Molecules Using Self-Reporting Fluorescent Nanodiamond Quantum Sensors

We devised a nanoscale sensor based on nanodiamonds to monitor and quantitatively assess the distribution of H₂O₂ molecules inside living cells, with molecular-level sensitivity. mehr

Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices

We report the synthesis of hybrid hydrogels by pH-controlled structural transition with exceptional rheological properties as cellular matrix. The strategy offers many attractive opportunities for 3D tissue engineering and other biomedical applications. mehr