Publications | Makromolecular Therapeutics Group Prof. Dr. Lutz Nuhn

Bixenmann, L.; Nuhn, L.: Hemiacetal Ester Side Chains as a Mild Protecting Group for Carboxylic Acids in Polycarbonate Backbones. Macromolecular Rapid Communications, 2500082 (2025)

Komforth, P.; Imschweiler, J.; Hesse, M.; Heck, A. G.; Fuchs, A.; Hauck, A. V.; Nuhn, L.: Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification. Biomacromolecules 26 (1), pp. 384 - 404 (2025)

Hauck, A. V.; Komforth, P.; Erlenbusch, J.; Stickdorn, J.; Radacki, K.; Braunschweig, H.; Besenius, P.; Hercke, S. V.; Nuhn, L.: Aliphatic polycarbonates with acid degradable ketal side groups as multi-pH-responsive immunodrug nanocarriers. Biomaterials Science (2024)

Bixenmann, L.; Ahmad, T.; Stephan, F.; Nuhn, L.: End-Group Dye-Labeled Poly(hemiacetal ester) Block Copolymers: Enhancing Hydrolytic Stability and Loading Capacity for Micellar (Immuno-)Drug Delivery. Biomacromolecules 25 (12), pp. 7958 - 7974 (2024)

Heck, A.; Nuhn, L.: Restoring the pH-responsiveness for amine-conjugated 2-propionic-3-methylmaleic anhydride linkers. Organic Chemistry Frontiers 11 (16), pp. 4380 - 4384 (2024)

Heck, A.; Schwiertz, D.; Lantzberg, B.; Nguyen, H.-C.; Forster, R.; Scherger, M.; Opatz, T.; Ginderachter, J. A. V.; Nuhn, L.: Introducing Targeting Units or pH-Releasable Immunodrugs into Core-Clickable Nanogels. European Polymer Journal 214, 113150 (2024)

Scherger, M.; Pilger, Y. A.; Komforth, P.; Räder, H. J.; Nuhn, L.: Reversible Polymer-Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers. ACS Biomaterials Science & Engineering 10 (1), pp. 129 - 138 (2024)

Scherger, M.; Pilger, Y. A.; Stickdorn, J.; Komforth, P.; Schmitt, S.; Arnouk, S. M.; Lebegge, E.; Koynov, K.; Räder, H. J.; Van Ginderachter, J. A. et al.; Nuhn, L.: Self‐Immolative Nanobody‐Cysteine Residue Modification for Controlled Immunodrug Delivery. Advanced Therapeutics 6 (11), 2300076 (2023)

Stickdorn, J.; Czysch, C.; Medina-Montano, C.; Stein, L.; Xu, L.; Scherger, M.; Schild, H.; Grabbe, S.; Nuhn, L.: Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses. International Journal of Molecular Sciences 24 (20), 15417 (2023)

Scherger, M.; Pilger, Y. A.; Stickdorn, J.; Komforth, P.; Schmitt, S.; Koynov, K.; Räder, H. J.; Nuhn, L.: Efficient Self-Immolative RAFT End Group Modification for Macromolecular Immunodrug Delivery. Biomacromolecules 24 (5), pp. 2380 - 2391 (2023)

Prudlik, A.; Mohebbati, N.; Hildebrandt, L.; Heck, A.; Nuhn, L.; Francke, R.: TEMPO-Modified Polymethacrylates as Mediators in Electrosynthesis: Influence of the Molecular Weight on Redox Properties and Electrocatalytic Activity. Chemistry – A European Journal 29 (11), e202202730 (2022)

Czysch, C.; Dinh, T.; Fröder, Y.; Bixenmann, L.; Komforth, P.; Balint, A.; Räder, H. J.; Naumann, S.; Nuhn, L.: Nontoxic N-Heterocyclic Olefin Catalyst Systems for Well-Defined Polymerization of Biocompatible Aliphatic Polycarbonates. ACS Polymers Au 2 (5), pp. 371 - 379 (2022)

Barz, M.; Nuhn, L.; Theato, P.: A Tribute to Rudolf Zentel and His Lifetime Research Achievements. Macromolecular Rapid Communications 43 (12), 2200311 (2022)

Huppertsberg, A.; Leps, C.; Alberg, I.; Rosenauer, C.; Morsbach, S.; Landfester, K.; Tenzer, S.; Zentel, R.; Nuhn, L.: Squaric Ester‐Based Nanogels Induce No Distinct Protein Corona but Entrap Plasma Proteins into their Porous Hydrogel Network. Macromolecular Rapid Communications 43 (19), 2200318 (2022)

Raabe, M.; Heck, A.; Führer, S.; Schauenburg, D.; Pieszka, M.; Wang, T.; Zegota, M. M.; Nuhn, L.; Ng, D. Y. W.; Kuan, S. L. et al.; Weil, T.: Assembly of pH-Responsive Antibody-Drug-Inspired Conjugates. Macromolecular Bioscience 22 (2), 2100299 (2022)

Czysch, C.; Medina-Montano, C.; Dal, N.-J. K.; Dinh, T. T. D.; Fröder, Y.; Winterwerber, P.; Maxeiner, K.; Räder, H. J.; Schuppan, D.; Schild, H. et al.; Bros, M.; Biersack, B.; Feranoli, F.; Grabbe, S.; Nuhn, L.: End Group Dye-labeled Polycarbonate Block Copolymers for Micellar (immuno-)Drug Delivery. Macromolecular Rapid Communications, 2200095 (2022)

Kabs, L.; Huppertsberg, A.; Choteschovsky, N.; Klefenz, A.; Dural, F.; Schrörs, B.; Diken, M.; Eichler, E.; Rosigkeit, S.; Schmitt, S. et al.; Leps, C.; Schulze, A.; Foerster, F.; Bockamp, E.; De Geest, B. G.; Koynov, K.; Räder, H.-J.; Tenzer, S.; Marini, F.; Schuppan, D.; Nuhn, L.: pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages. Proceedings of the National Academy of Sciences of the United States of America 119 (12), e2122310119 (2022)

Stickdorn, J.; Stein, L.; Arnold-Schild, D.; Hahlbrock, J.; Medina-Montano, C.; Bartneck, J.; Ziß, T.; Montermann, E.; Kappel, C.; Hobernik, D. et al.; Haist, M.; Yurugi, H.; Raabe, M.; Best, A.; Rajalingam, K.; Radsak, M. P.; David, S. A.; Koynov, K.; Bros, M.; Grabbe, S.; Schild, H.; Nuhn, L.: Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors. ACS Nano 16 (3), pp. 4426 - 4443 (2022)

Schmitt, S.; Huppertsberg, A.; Klefenz, A.; Kaps, L.; Mailänder, V.; Schuppan, D.; Butt, H.-J.; Nuhn, L.; Koynov, K.: Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream. Biomacromolecules 23 (3), pp. 1065 - 1074 (2022)

Schmitt, S.; Nuhn, L.; Barz, M.; Butt, H.-J.; Koynov, K.: Shining Light on Polymeric Drug Nanocarriers with Fluorescence Correlation Spectroscopy. Macromolecular Rapid Communications 43 (12), 2100892 (2022)