Job Offer from October 30, 2024
Ferroptosis is a novel type of cell death driven by lipid peroxidation. Classically, ferroptosis is triggered by inhibiting cellular antioxidant systems. However, to initiate lipid oxidation, free radicals are required. We will investigate the important question in understanding ferroptosis where in the cell and which free radicals are triggering lipid oxidation. This work will be part of a collaboration work with the computational PhD project simulating lipid peroxidation.
Time Frame: February 2025 onwards
Methods: Preparation and characterization of liposomes, biochemical assays, fluorescent microscopy, cell culture, and cellular biosensors.
Requirements: Master in Biochemistry, Chemistry, or related fields
Related publications:
Barayeu, U., Schilling, D., Eid, M. et al. Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals. Nature Chemical Biology (2023). https://doi.org/10.1038/s41589-022-01145-w
Zijun Wu, Uladzimir Barayeu, Danny Schilling, Tobias P. Dick, Derek A. Pratt, Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death, Current Opinion in Chemical Biology, 2023. doi.org/10.1016/j.cbpa.2023.102353.